SMI Adviser Long-Acting Injectable Center of Excellence

Education, resources, and evidence-based answers to help you optimize the use of LAIs
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SMI Adviser Long-Acting Injectable Center of Excellence

The Long-Acting Injectable (LAI) Center of Excellence (COE) provides FREE resources, education, consultation, tools and more on the use of LAIs. Let SMI Adviser help you increase and improve the use of LAIs in individuals with schizophrenia and bipolar disorder. The LAI COE is led by SMI Adviser Nursing Expert, Donna Rolin, PhD, APRN, and SMI Adviser Physician Expert, Robert Cotes, MD, and supported by members of the LAI Workgroup.

For individual and family resources on using long-acting injectables, visit the individual and family Knowledge Base.

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Clinician’s Guide to Preparing and Administering Long-Acting Injectable Antipsychotics

Strategies for Success: Using Long-Acting Injectable Medications

Adherence to Antipsychotics in Schizophrenia: Clinical Considerations

Evaluating Adverse Drug Effects

Long-Term Antidepressant Treatment: Let’s Look at the Evidence

Managing the Side Effects of Psychotropic Medications

Maximizing Treatment Success for Patients with SMI: Promoting Adherence and Treatment Engagement

Psychotropic Medications and Older Adults: Update on Safety Considerations

Join the Clozapine and LAI Centers of Excellence Exchange

The Clozapine and LAI Centers of Excellence Exchange engages psychiatrists, nurses/nurse practitioners, pharmacists, and other clinicians, providing an opportunity to collaborate on the use of clozapine and long-acting injectables.

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Clozapine & LAI Virtual Forum

Join us for a live peer-to-peer discussion each month to share your challenges and questions on trending topics around clozapine and LAIs. Sign up for the Clozapine and LAI Centers of Excellence Exchange above to receive email invitations.

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Get Expert Guidance on Questions Around LAIs

Submit any questions you have on managing side effects, assessment and monitoring, medical comorbidities, and any other topic. Receive a response within one business day from one of our national experts.

How should long-acting injectables be initiated?
How much oral overlap is recommended with the first-generation antipsychotic decanoates?
What are the main differences between the aripiprazole long-acting injectables (LAIs)?

Trending Topics

Use our Knowledge Base to find evidence-based answers and resources on LAIs. Here are some new and popular topics — all vetted by our Clinical Expert Team.

What do APA’s Schizophrenia Treatment Guidelines say about long-acting injectable antipsychotics?

On September 1, 2020, the American Psychiatric Association released a new evidence-based “Practice Guideline for the Treatment…

What long-acting injectable (LAI) antipsychotic medications are available in the U.S.?

See clinical tips available (linked below) on individual LAIs for more detailed information about what clinicians should…

What should clinicians know about Perseris (risperidone subcutaneous LAI)?

Perseris is a long-acting injectable (LAI) formulation of risperidone. It is the first available antipsychotic LAI available…

What mistakes should providers be aware of when prescribing and administering long-acting injectables (LAIs)?

Mistakes in preparation:

Not all injections are given the same way. Aristada (aripiprazole lauroxil) is the most…

How do I treat an acute dystonic reaction (ADR)?

ADRs are best avoided as this acute neurological side effect is painful, frightening and, in the case…

How are prolactin levels impacted by long-acting injectable (LAI) antipsychotic medications?

Hyperprolactinemia is often caused by the use of antipsychotic medications, and this with both oral and LAI…

What can be done if a LAI medication becomes less effective part way through the inter-injection interval?

There are several reasons why a LAI medication might have diminished efficacy through the inter-injection interval.

What are clinical considerations for giving LAIs during the COVID-19 public health emergency?

Since LAI antipsychotics need to be administered in person, some planning…

I am going to start a new long-acting injectable antipsychotic (LAI) medication soon. I’m worried about how much injections hurt when I get them in my arm, so are there other options about where to get the shot?

There are many different options of LAIs available. See this SMI Adviser tip on those available.

Several…

What is shared decision making and how does it apply to using long-acting injectables (LAIs)?

Shared Decision Making (SDM) is a collaborative process between a patient and clinician. See this SMI Adviser tip…

Tips on Starting or Switching LAIs

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Tips on Administration and Monitoring

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Management of Side Effects

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Tips on Challenges

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Information and Handouts for Individuals and Families

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View Past Recordings

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