What long-acting injectable (LAI) antipsychotic medications are available in the U.S.?

See clinical tips available (linked below) on individual LAIs for more detailed information about what clinicians should know.

LAI Drug Name

FDA Indications

(Adult 18+ unless otherwise noted*)

Dosing Tips

(frequency of administration, oral overlap)

***First Generation Antipsychotics***

Schizophrenia

2-6 weeks
Overlap PO 4-8 weeks

Schizophrenia

4 weeks
Overlap PO 4 weeks

***Second Generation Antipsychotics***

Schizophrenia
Bipolar maintenance

4 weeks
Overlap PO 2 weeks

Schizophrenia

4 or 6 or 8 weeks
Aristada Initio IM & PO 1 dose or
Overlap PO 3 weeks

Schizophrenia

Only for initiation of Aristada once
Given with Aristada first injection

Schizophrenia

4 weeks
Loading IM day 1 & day 8

Schizophrenia

12 weeks
After 2 stable-dose Sustenna injections

Schizophrenia *age 13+
Bipolar I maintenance *age12+

2 weeks
Overlap PO 3 weeks

Schizophrenia

4 weeks
Subcutaneous (SC)

Schizophrenia

2 or 4 weeks
Smoking status dosing considerations
Risk: Post-injection delirium sedation syndrome (PDSS) – registry required

If you would like more information on this topic, or would like to provide any feedback, please send us a message using our consultation system. Be sure to let us know about which tip you are writing. We would love to hear from you, and the consultation system is free to use and confidential. Thank you!
Type: Knowledge Base
Answered by:
SMI Adviser LAI Workgroup
Date Answered: February 7, 2020
Topic: Psychopharmacology, 
Tags: Long-acting Injectables, 
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