What long-acting injectable (LAI) antipsychotic medications are available in the U.S.?

LAI Drug Name

FDA Indications

(Adult 18+ unless otherwise noted*)

Dosing Tips

(frequency of administration, oral overlap)

***First Generation Antipsychotics***

Haldol Decanoate (haloperidol decanoate)

Schizophrenia

4 weeks

Prolixin Decanoate (fluphenazine decanoate) 

Schizophrenia

2-6 weeks
Overlap PO 4-8 weeks

***Second Generation Antipsychotics***

Abilify Asimtufii (aripiprazole LAI)

Schizophrenia 
Bipolar maintenance

8 weeks
Overlap PO 2 weeks

Abilify Maintena (aripiprazole monohydrate LAI)

Schizophrenia 
Bipolar maintenance 

4 weeks
Overlap PO 2 weeks

Aristada (aripiprazole lauroxil LAI)

Schizophrenia

4 or 6 or 8 weeks
Aristada Initio IM & PO 1 dose or
Overlap PO 3 weeks

Aristada Initio (aripiprazole lauroxil LAI)

Initiation of Maintenance Aristada (aripiprazole lauroxil LAI) in Schizophrenia

Only for initiation of Aristada once
Given with Aristada first injection

Invega Sustenna (paliperidone palmitate LAI)

Schizophrenia
Schizoaffective Disorder

4 weeks
Loading IM day 1 & day 8

Invega Hafyera (paliperidone palmitate 6-month LAI)

Schizophrenia

6 months; after adequately treated with INVEGA SUSTENNA for at least 4 months OR INVEGA TRINZA for at least one three-month cycle

Invega Trinza (paliperidone palmitate 12-week LAI)

Schizophrenia

12 weeks; after adequately treated with INVEGA SUSTENNA for at least four months, with the last 2 doses of INVEGA SUSTENNA at the same dosage strength

Perseris (risperidone subcutaneous LAI)

Schizophrenia

4 weeks
Subcutaneous (SC)

Risperdal Consta (risperidone microspheres LAI)

Schizophrenia 
Bipolar I maintenance 

2 weeks
Overlap PO 3 weeks

Uzedy (risperidone subcutaneous LAI)

Schizophrenia

4 or 8 weeks

Zyprexa Relprevv (olanzapine LAI)

Schizophrenia

2 or 4 weeks
Smoking status dosing considerations
Risk: Post-injection delirium sedation syndrome (PDSS) – registry required