What long-acting injectable (LAI) antipsychotic medications are available in the U.S.?

LAI Drug Name

(Adult 18+ unless otherwise noted*)

Dosing Tips

(frequency of administration, oral overlap)

Schizophrenia

• 2-6 weeks
• Overlap PO 4-8 weeks

Schizophrenia

• 4 weeks
• Overlap PO 4 weeks

Schizophrenia

Bipolar maintenance

• 4 weeks
• Overlap PO 2 weeks

Schizophrenia

• 4 or 6 or 8 weeks
• Aristada Initio IM & PO 1 dose or
• Overlap PO 3 weeks

Schizophrenia

• Only for initiation of Aristada once
• Given with Aristada first injection

Schizophrenia

• 4 weeks
• Loading IM day 1 & day 8

Schizophrenia

• 12 weeks
• After 2 stable-dose Sustenna injections

Schizophrenia *age 13+

Bipolar I maintenance *age12+

• 2 weeks
• Overlap PO 3 weeks

Schizophrenia

• 4 weeks
• Subcutaneous (SC)

Schizophrenia

• 2 or 4 weeks
• Smoking status dosing considerations
• Risk: Post-injection delirium sedation syndrome (PDSS) – registry required.