What long-acting injectable (LAI) antipsychotic medications are available in the U.S.?

See clinical tips available (linked below) on individual LAIs for more detailed information about what clinicians should know.

LAI Drug Name

FDA Indications

(Adult 18+ unless otherwise noted*)

Dosing Tips

(frequency of administration, oral overlap)

***First Generation Antipsychotics***


2-6 weeks
Overlap PO 4-8 weeks


4 weeks
Overlap PO 4 weeks

***Second Generation Antipsychotics***

Bipolar maintenance

4 weeks
Overlap PO 2 weeks


4 or 6 or 8 weeks
Aristada Initio IM & PO 1 dose or
Overlap PO 3 weeks


Only for initiation of Aristada once
Given with Aristada first injection


4 weeks
Loading IM day 1 & day 8


12 weeks
After 2 stable-dose Sustenna injections

Schizophrenia *age 13+
Bipolar I maintenance *age12+

2 weeks
Overlap PO 3 weeks


4 weeks
Subcutaneous (SC)


2 or 4 weeks
Smoking status dosing considerations
Risk: Post-injection delirium sedation syndrome (PDSS) – registry required

If you would like more information on this topic, or would like to provide any feedback, please send us a message using our consultation system. Be sure to let us know about which tip you are writing. We would love to hear from you, and the consultation system is free to use and confidential. Thank you!
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