What long-acting injectable (LAI) antipsychotic medications are available in the U.S.?

See clinical tips available (linked below) on individual LAIs for more detailed information about what clinicians should know.

 

LAI Drug Name

FDA Indications

(Adult 18+ unless otherwise noted*)

Dosing Tips

(frequency of administration, oral overlap)

***First-Generation Antipsychotics***
Prolixin Decanoate (fluphenazine decanoate) 

Schizophrenia

  • 2-6 weeks
  • Overlap PO 4-8 weeks
Haldol Decanoate (haloperidol decanoate)

Schizophrenia

  • 4 weeks
  • Overlap PO 4 weeks
***Second-Generation Antipsychotics***
Abilify Maintena (aripiprazole LAI)

Schizophrenia

Bipolar maintenance

  • 4 weeks
  • Overlap PO 2 weeks
Aristada (aripiprazole lauroxil LAI)

Schizophrenia

  • 4 or 6 or 8 weeks
  • Aristada Initio IM & PO 1 dose or
  • Overlap PO 3 weeks
Aristada Initio (aripiprazole lauroxil LAI)

Schizophrenia

  • Only for initiation of Aristada once
  • Given with Aristada first injection
Invega Sustenna (paliperidone palmitate LAI)

Schizophrenia

  • 4 weeks
  • Loading IM day 1 & day 8
Invega Trinza (paliperidone palmitate 12-week LAI)

Schizophrenia

  • 12 weeks
  • After 2 stable-dose Sustenna injections
Risperdal Consta (risperidone IM LAI)

Schizophrenia *age 13+

Bipolar I maintenance *age12+

  • 2 weeks
  • Overlap PO 3 weeks
Perseris (risperidone SC LAI)

Schizophrenia

  • 4 weeks
  • Subcutaneous (SC)
Zyprexa Relprevv (olanzapine LAI)

Schizophrenia

  • 2 or 4 weeks
  • Risk: Post-injection delirium sedation syndrome (PDSS) – registry required.
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