What long-acting injectable (LAI) antipsychotic medications are available in the U.S.?

See clinical tips available (linked below) on individual LAIs for more detailed information about what clinicians should know.

LAI Drug Name

FDA Indications

(Adult 18+ unless otherwise noted*)

Dosing Tips

(frequency of administration, oral overlap)

***First Generation Antipsychotics***

Schizophrenia

2-6 weeks
Overlap PO 4-8 weeks

Schizophrenia

4 weeks

***Second Generation Antipsychotics***

Schizophrenia (ages 13+)
Bipolar maintenance (ages 12+)

4 weeks
Overlap PO 2 weeks

Schizophrenia

4 or 6 or 8 weeks
Aristada Initio IM & PO 1 dose or
Overlap PO 3 weeks

Schizophrenia

Only for initiation of Aristada once
Given with Aristada first injection

Schizophrenia

4 weeks
Loading IM day 1 & day 8

Schizophrenia

12 weeks; after adequately treated with INVEGA SUSTENNA for at least four months, with the last 2 doses of INVEGA SUSTENNA at the same dosage strength  

Schizophrenia

6 months; after adequately treated with INVEGA SUSTENNA for at least 4 months OR INVEGA TRINZA for at least one three-month cycle

Schizophrenia 
Bipolar I maintenance 

2 weeks
Overlap PO 3 weeks

Schizophrenia

4 weeks
Subcutaneous (SC)

Schizophrenia

2 or 4 weeks
Smoking status dosing considerations
Risk: Post-injection delirium sedation syndrome (PDSS) – registry required

References:

1. INVEGA TRINZA USPI, Section 1: Indications and Usage; Section 2.2: Schizophrenia 
2. INVEGA HAFYERA USPI, Section 1: Indications and Usage

3. RISPERDAL CONSTA USPI, Section 8.4: Pediatric Use 
4. HALDOL DECANOATE USPI 

If you would like more information on this topic, or would like to provide any feedback, please send us a message using our consultation system. Be sure to let us know about which tip you are writing. We would love to hear from you, and the consultation system is free to use and confidential. Thank you!
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