What should I consider and how do I change or switch a patient from a different long acting injectable medication (LAI) to Abilify Maintena?

When changing or switching from a different LAI to aripiprazole LAI (Abilify Maintena), stop the current LAI and follow the guidance for using Abilify Maintena, including this guidance with regard to establishing tolerability. Detailed protocols for switching between LAIs have not been established, but it is recommended that there is overlap of 1-3 weeks when switching to oral aripiprazole. Therefore, prescribers should stop the previous LAI and initiate the new LAI when possible.

When thinking about the dose of the new LAI, exact equivalent dosages between antipsychotics are not known. Additionally, side effects can vary substantially between antipsychotic medications. A meta-analysis of dosage curves found the following dosages to have similar efficacy in patients who had success on each medication.

FDA medication label

  • Information on this topic is found in the FDA medication label. Here is the most recent label, at time of writing.
  • Medication labels can be found by searching Drugs@FDA at the FDA website. Labels are also available using the Drugs@FDA app for Apple or Android devices. Labels change over time, and the current label should always be consulted.
If you would like more information on this topic, or would like to provide any feedback, please send us a message using our consultation system: www.smiadviser.org/submit-consult. Be sure to let us know about which tip you are writing. We would love to hear from you, and the consultation system is free to use and confidential. Thank you!

 

REFERENCES

Stahl, S. M. (2017). The prescriber’s guide: Stahl’s essential psychopharmacology (6th ed.). New York: Cambridge University Press.

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