When changing or switching from a different LAI to aripiprazole LAI (Abilify Maintena), stop the current LAI and follow the guidance for using Abilify Maintena, including this guidance with regard to establishing tolerability. Detailed protocols for switching between LAIs have not been established, but it is recommended that there is overlap of 1-3 weeks when switching to oral aripiprazole. Therefore, prescribers should stop the previous LAI and initiate the new LAI when possible.
When thinking about the dose of the new LAI, exact equivalent dosages between antipsychotics are not known. Additionally, side effects can vary substantially between antipsychotic medications. A meta-analysis of dosage curves found the following dosages to have similar efficacy in patients who had success on each medication.
FDA medication label
Stahl, S. M. (2017). The prescriber’s guide: Stahl’s essential psychopharmacology (6th ed.). New York: Cambridge University Press.