Dr. Keedy will review her research and clinical experience with emphasis on the range of intact to impaired neurocognition observed in individuals with psychotic and bipolar-type disorders. She will highlight how these observations are being used in current research studies to determine more efficient treatment selection and improved outcomes. A highlight of this work is the identification of groups of patients with similarities on cognition and other measures. She will use clinical case examples to demonstrate the impact of more vs less cognitive impairment when conducting evidence-informed cognitive behavior interventions, and she will describe how the current research could be applied in the future to the cases to improve outcomes.