Vision side effects of clozapine

While it is uncommon, clozapine can cause changes in vision as a side effect. Clozapine has anticholinergic activity, acting at muscarinic receptors. The most common visual side effect of anticholinergic medications is loss of accommodation. This can cause a decrease in the ability to focus on near objects and blurred vision at reading distance. With decreased accommodation, reading glasses may be necessary. Blurred vision at reading distance can be corrected with glasses. Anticholinergic medications can also cause pupil dilation, resulting in sensitivity to bright light.

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