Salivation Side Effect with Clozapine

A common side effect of clozapine is drooling or the appearance of excess saliva, also known as sialorrhea. This is caused by decreased swallowing, leading to increased saliva in the mouth. Drooling usually happens while sleeping, and sometimes occurs during the day. This is typically not a dangerous side effect. However, it can be bothersome or make the patient appear odd. Treatment strategies include sleeping with a towel on the pillow. Also, chewing sugarless gum during the day stimulates the swallowing reflex, and can be helpful. Medications can be added by the patient’s provider, though have a risk of creating their own side effects. Peer-run support groups that directly address living with side effects can be helpful.

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