The dosage of clozapine is titrated up gradually, to minimize side effects and maximize effectiveness. Titration starts with 12.5 mg once daily or twice daily. The total daily dosage is often increased by increments of 25 or 50 mg per day, every 2 or 3 days, as tolerated. The rate of titration is adjusted by your clinician based on risk for side effects, side effects experienced, and effectiveness. Titration continues at a similar rate to between 300 and 450 mg per day, when substantial efficacy often becomes apparent. If it has been more than two days since the patient last took clozapine, their dosage should be substantially reduced. Talk with your clinician about dosages of clozapine.