Is it possible to help individuals who have SMI to quit smoking?

There is strong evidence that treatment for nicotine use disorder is both efficacious and tolerable for individuals who have SMI. In fact, it is comparable to that for persons without SMI. The most effective treatments include varenicline and bupropion (versus nicotine replacement and placebo) for sustained remission of six months or more.

Learn more about common myths around SMI and treatment, including nicotine use. See our infographic on this topic.



  • Roberts, E., Evins, A.E., McNeill, A., & Robson, D. (2016). Efficacy and tolerability of pharmacotherapy for smoking cessation in adults with serious mental illness: A systematic review and network meta-analysis. Addiction. 111:599-612. doi:10.1111/add.13236
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