Is “clinical high risk” a valid clinical construct?

The early identification of individuals who have an increased risk for psychosis may allow clinicians to intervene more promptly. This can potentially alter the trajectory of the illness.

In an umbrella review summarizing 42 meta-analyses, among individuals who met CHR-P criteria, the risk of conversion to psychosis was 22% at three years among individuals who met CHR-P criteria.

Learn more about common myths around SMI and treatment, including clinical high risk. See our infographic on this topic.



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  • Miller TJ, McGlashan TH, Rosen JL, et al: Prodromal assessment with the structured interview for prodromal syndromes and the scale of prodromal symptoms: predictive validity, interrater reliability, and training to reliability. Schizophr Bull 29:703-715, 2003
  • Yung AR, Yuen HP, McGorry PD, et al: Mapping the onset of psychosis: the Comprehensive Assessment of At-Risk Mental States. Aust N Z J Psychiatry 39:964-971, 2005
  • Fusar-Poli P, Salazar de Pablo G, Correll CU, et al: Prevention of Psychosis: Advances in Detection, Prognosis, and Intervention. JAMA Psychiatry 77:755-765, 2020
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