Clozapine Found More Effective Than Other Antipsychotics in Real-World Settings

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This comprehensive meta-analysis of cohort studies, reflecting clinical practice more than RCTs, found clozapine to be associated with better effectiveness outcomes than [other second-generation antipsychotics], despite more severely ill patients being treated with clozapine, but with significantly greater risk of cardiometabolic adverse outcomes, both of which require consideration when making treatment choices,” the authors concluded.

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