Understand why agitation is such an important concept (in terms of being an emergency medical condition as well as its role in patient suffering) and investigate proper framing and engagement for interacting with those suffering from agitation. This will include an overview of de-escalation principles as well as psychological first aid and trauma centered processing. The next portion of the webinar will then focus on the psychopharmacologic treatment of agitation. We will cover not only the usual suspects (antipsychotics, anxiolytics, and sedatives) but also more recent offerings to the field (ketamine, anesthetics, and unique delivery systems). The webinar will then conclude with practical approaches to not only using these methods but also for gaining momentum within one’s organization as to this culture shift. At this point, we can then conclude with how the proper treatment of agitation (both proactive and reactive) leads to improvements in both our patients and the staff who care for them with dedication and empathy.