Large numbers of patients with serious mental illness (SMI) are not adherent to medications and treatment modalities, not only impacting their overall symptoms management but their also impairing quality of life. Less than 50% of patients with SMI continue to take their medications and adhere to their plan of care after 6 months. Non-adherence increases the risk of hospitalization, decreases recovery efforts, and extends the time in which a person will spend in inpatient facilities. It is estimated that hospitalizations due to non-adherence costs more than $100 billion a year in the United States. It is not unusual for many people with chronic SMI who do seek help to drop out from continued treatment after one or two visits. An estimated 70% of such individual stop receiving treatment due to poor interactions with their providers or lack of understanding about the need for their treatment. It is important that patients with SMI are active participants in their care with providers and the community supports in a process called shared decision making. Engaging patients in their care not only boosts adherence but also improves patients’ overall outcomes. Strategies to improve adherence to medications and treatment plans for patients with SMI will be explored in this webinar, including long-acting injectable medications (when indicated), medication strategies, and adjunctive supports.