This presentation hopes to provide clarity on the effects of cannabis on Major Depressive Disorder. The talk starts with a brief overview of the endogenous cannabinoid system to explore its functions. We then explore how whole cannabis – with THC, CBD, terpenes, and flavonoids – has different effects than purified THC, CBD, or both combined (THC:CBD).
Finally, we review the literature on the effects of whole cannabis, THC, or CBD on patients with Major Depressive Disorder.
Afterwards, the listener will be better able to counsel their patients with MDD who use cannabis. They will also be able to critically consume future literature on whole cannabis, THC, and CBD and determine its applicability to their patients.