This webinar will provide updated clinically-orientated information on a clozapine adverse drug reaction that is often under-recognized and poorly managed – gastrointestinal hypomotility. A series of aligned pharmacovigilance, psychopharmacological and gastroenterological studies using translational techniques (e.g., spatiotemporal mapping and wireless motility capsules) will be described and summarized. Radiopaque marker and wireless motility capsule studies show gastroparesis and delayed colonic transit are more common than not in people taking clozapine, with over three-quarters developing gastrointestinal hypomotility. Strategies for recognizing and managing clozapine induced gastrointestinal hypomotility are described. Prophylactic laxatives are recommended with clozapine use. The risks with clozapine use can be recognized and managed effectively. Key strategies for prevention, identification and management will be presented.