SMI Adviser Clozapine Center of Excellence

Education, resources, and evidence-based answers to help you optimize the use of Clozapine
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Welcome to the Clozapine Center of Excellence (COE)

SMI Adviser created the Clozapine COE to promote the safe and effective use of clozapine. The ultimate goal of this effort is to improve the lives of individuals who have treatment-resistant schizophrenia. The Clozapine COE provides clinicians with training opportunities, technical assistance, and vetted resources. These include:

  • Live and on-demand webinars
  • Virtual Learning Collaboratives
  • Virtual Forums
  • Email listserv
  • On-demand consultations
  • Intensive consultation to sites or communities
  • Clinical tips and resources

The Clozapine COE is led by SMI Adviser Physician Expert, Robert Cotes, MD, SMI Nursing Expert, Donna Rolin, PhD, APRN, and SMI Adviser content partner, National Association of State Mental Health Program Directors (NASMHPD), and supported by members of the Clozapine Workgroup.

For individual and family resources on using clozapine, visit the individual and family Knowledge Base.

After 30 years,

clozapine is still best for treatment-resistant patients

  • Resources
  • Education
  • Join Us
  • Consultation
Clozapine & LAI Virtual Forum – August 2020 (Video) – Clozapine hematologic monitoring and COVID-19

The Clozapine & LAI Virtual Forum gathers prescribers together each month to discuss a hot topic. Drop…

Clozapine & LAI Virtual Forum – September 2020 (Video) – Antipsychotic conversion to LAIs

The Clozapine & LAI Virtual Forum gathers prescribers together each month to discuss a hot topic. Drop…

How Culture Impacts Mental Health and Treatment (Video)

Watch this video to learn about how culture impacts health and treatment from Maxie Gordon, MD.

Mental Health Care and Cultural Competence (Video)

Watch this video to learn about mental health care and cultural competence from Maxie Gordon, MD.

2019 NAMICon Session: Cultural Competence in Psychiatry (Video)

This webinar will provide an overview of cultural psychiatry. It will provide an overview of how…

Are You Born With It? (Video)

Although mental health conditions are biological, they are caused by a complex combination of genetic and…

Becoming a Culturally Competent Provider (Video)

Watch this video to learn about becoming a culturally competent provider from Maxie Gordon, MD.


How Culture Impacts Mental Health and Treatment (Video)

Watch this video to learn about how culture impacts health and treatment from Maxie Gordon, MD.

How Messages Travel Through The Brain (Video)

The human brain is the organ we know the least about and is by far the…

How Psychotropic Medications Work (Video)

Medication can be an important part of treatment for any physical condition, including mental health. For…

Join the Clozapine and LAI Centers of Excellence Exchange

The Clozapine and LAI Centers of Excellence Exchange engages psychiatrists, nurses/nurse practitioners, pharmacists, and other clinicians, providing an opportunity to collaborate on the use of clozapine and long-acting injectables. Sign up for this listserv and join the conversation!

Sign Up Now

Clozapine & LAI Virtual Forum

Join us for a live peer-to-peer discussion each month to share your challenges and questions on trending topics around clozapine and LAIs. Sign up for the Clozapine and LAI Centers of Excellence Exchange above to receive email invitations.

View Past Recordings

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Check out these sample questions as a good place to start:

What should I do about salivation with clozapine?
What are the top benefits of LAIs?
What do you think will be the next game changer in antipsychotic treatment?

Trending Topics

Use our Knowledge Base to find evidence-based answers and resources on Clozapine. Here are some new and popular topics — all vetted by our Clinical Expert Team.

Clozapine Blood Count Monitoring

In the United States, the Food and Drug Administration requires regular blood count monitoring of all patients…

Clozapine Brochure

If you are one of the 3 in 10 people with schizophrenia or a related condition…

Can clozapine cause problems with urine or urination, such as incontinence or enuresis?

Urinary incontinence is a side effect that has been reported in between 1% and 20% of patients…

Clozapine Orthostatic Hypotension, Bradycardia, Syncope Side Effect

Orthostatic hypotension is a drop in blood pressure when changing from lying or sitting to standing. This…

Clozapine Seizure Side Effect

Seizures are an uncommon, but potentially serious side effect of clozapine. Between 2% and 4% of individuals…

Clozapine Tachycardia Side Effect

Most people have a resting heart rate between 60 and 100 beats per minute. A 15-minute brisk…

Constipation Side Effect of Clozapine

Constipation is a common and potentially very serious side effect of clozapine.  Constipation can result in a…

How does clozapine work and how is it different from other medications?

Clozapine is a medication used for treatment-resistant schizophrenia and sometimes treatment-resistant bipolar disorder. It is classified as…

How do I interpret clozapine or norclozapine blood, serum or plasma levels, what do these mean?

Clinician assessment of symptoms and side effects is the primary means of evaluating and adjusting clozapine treatment.…

How does one dose or titrate clozapine dosage when starting on this medication?

The dosage of clozapine is titrated up gradually, to minimize side effects and maximize effectiveness. Titration starts…

I’ve heard about close lab monitoring with clozapine. What happens if the ANC level gets low when someone is taking clozapine?

There are numerous types of white blood cells (WBC) that help fight infections in the body. A…

Tips on starting Clozapine


Tips on Monitoring


Tips on Common Side Effects


Tips on Important Uncommon Side Effects


Tips on Challenges


Guidelines, Research, & Tools


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